New Material That Inhibits Biofilm Formation Of A Virulent Superbug





Science, 01 Aug - 2017 ,

New Material That Inhibits Biofilm Formation Of A Virulent Superbug
Credit: bvwater.co.uk

By some estimates, bacterial strains resistant to antibiotics so-called superbugs will cause more deaths than cancer by 2050.

By some estimates, bacterial strains resistant to antibiotics so-called superbugs  will cause more deaths than cancer by 2050.

Colorado State University biomedical and chemistry researchers are using creative tactics to subvert these superbugs and their mechanisms of invasion. In particular, they're devising new ways to keep harmful bacteria from forming sticky matrices called biofilms  and to do it without antibiotic drugs.

Researchers from the laboratory of Melissa Reynolds, associate professor of chemistry and the School of Biomedical Engineering, have created a new material that inhibits biofilm formation of the virulent superbug Pseudomonas aeruginosa. Their material, described in Advanced Functional Materials, could form the basis for a new kind of antibacterial surface that prevents infections and reduces our reliance on antibiotics.

Bella Neufeld, the first author and graduate student who led the research, explained that her passion for finding new ways to fight superbugs is motivated by how adaptive and impenetrable they are, especially when they are allowed to form biofilms.

When bacteria attach

Many people picture bacteria and other microorganisms in their friendlier, free-floating state -- like plankton swimming in a high school petri dish. But when bacteria are able to attach to a surface and form a biofilm, they become stronger and more resistant to normal drugs.

In a classic example, cystic fibrosis patients are sickened by hordes of P. aeruginosa bacteria forming a sticky film on the endothelial cells of the patients' lungs. Once those bacteria attach, drugs won't kill them.

Or, a wound can become infected with a bacterial biofilm, making it more difficult for that wound to heal.

85 percent reduction

Researcher demonstrated an 85 percent reduction in P. aeruginosa biofilm adhesion. They conducted extensive studies showing the reusability of their film. This indicated that its antibacterial properties are driven by something inherent in the material, so its efficacy wouldn't fade in a clinical setting.

They used a material they've worked with before for other antimicrobial applications, a copper-based metal-organic framework that's stable in water. They embedded the copper metal-organic framework within a matrix of chitosan, a material derived from the polysaccharide chitin, which makes up insect wings and shrimp shells. Chitosan is already widely used as a wound dressing and hemostatic agent.

Neufeld says the new biomaterial could form new avenues for antibacterial surfaces. For example, the material could be used for a wound dressing that, instead of gauze, would be made of the chitosan matrix.

 


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